Markedly Reduced Thermal Pain Perception in a Schizoaffective Patient with Tardive Dyskinesia
Identifieur interne : 000703 ( Main/Exploration ); précédent : 000702; suivant : 000704Markedly Reduced Thermal Pain Perception in a Schizoaffective Patient with Tardive Dyskinesia
Auteurs : Stéphane Potvin [Canada] ; Emmanuel Stip [Canada] ; Serge Marchand [Canada]Source :
- Case Reports in Psychiatry [ 2090-682X ] ; 2016.
Abstract
Several case reports have described stories of schizophrenia patients reporting no discomfort in response to several medical conditions which normally elicit pain. Comparatively, experimental studies performed on pain perception in schizophrenia have not documented hypoalgesic responses that are as frank as those reported in these clinical cases. Here, we report the case of a female patient with schizoaffective disorder, who displayed markedly reduced pain perception during an experimental heat pain paradigm. Compared to a large group of healthy volunteers that we tested in 3 previous studies using the same psychophysical procedure, the experimental temperature required to induce moderate pain was radically increased in this patient (
Url:
DOI: 10.1155/2016/8702483
PubMed: 27144045
PubMed Central: 4842046
Affiliations:
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sort="Potvin, Stephane" uniqKey="Potvin S" first="Stéphane" last="Potvin">Stéphane Potvin</name><affiliation wicri:level="1"><nlm:aff id="I1">Centre de Recherche de l'Institut Universitaire en Santé Mentale de Montréal, 7331 Hochelaga, Montreal, QC, Canada H1N 3V2</nlm:aff><country>Canada</country><wicri:regionArea>Centre de Recherche de l'Institut Universitaire en Santé Mentale de Montréal, 7331 Hochelaga, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Department of Psychiatry, Faculty of Medicine, University of Montreal, C.P. 6128, succursale Centre-ville, Montreal, QC, Canada H3C 3J7</nlm:aff><country>Canada</country><wicri:regionArea>Department of Psychiatry, Faculty of Medicine, University of Montreal, C.P. 6128, succursale Centre-ville, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Stip, Emmanuel" sort="Stip, Emmanuel" uniqKey="Stip E" first="Emmanuel" last="Stip">Emmanuel Stip</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Psychiatry, Faculty of Medicine, University of Montreal, C.P. 6128, succursale Centre-ville, Montreal, QC, Canada H3C 3J7</nlm:aff><country>Canada</country><wicri:regionArea>Department of Psychiatry, Faculty of Medicine, University of Montreal, C.P. 6128, succursale Centre-ville, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Centre Hospitalier de l'Université de Montréal, 1560 Sherbrooke East, Montreal, QC, Canada H2L 4M1</nlm:aff><country>Canada</country><wicri:regionArea>Centre Hospitalier de l'Université de Montréal, 1560 Sherbrooke East, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Marchand, Serge" sort="Marchand, Serge" uniqKey="Marchand S" first="Serge" last="Marchand">Serge Marchand</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Surgery, Faculty of Medicine, University of Sherbrooke, 3001 12e avenue Nord, Sherbrooke, QC, Canada J1H 5N4</nlm:aff><country>Canada</country><wicri:regionArea>Department of Surgery, Faculty of Medicine, University of Sherbrooke, 3001 12e avenue Nord, Sherbrooke, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author></analytic><series><title level="j">Case Reports in Psychiatry</title><idno type="ISSN">2090-682X</idno><idno type="eISSN">2090-6838</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Several case reports have described stories of schizophrenia patients reporting no discomfort in response to several medical conditions which normally elicit pain. Comparatively, experimental studies performed on pain perception in schizophrenia have not documented hypoalgesic responses that are as frank as those reported in these clinical cases. Here, we report the case of a female patient with schizoaffective disorder, who displayed markedly reduced pain perception during an experimental heat pain paradigm. Compared to a large group of healthy volunteers that we tested in 3 previous studies using the same psychophysical procedure, the experimental temperature required to induce moderate pain was radically increased in this patient (<italic>z</italic>-score = 3.6). The patient had mild psychiatric symptoms and had insight into her symptoms. She had drug-induced dyskinetic symptoms. This case report illustrates that it is possible to observe marked reductions in pain perception in schizophrenia patients tested in experimental settings but that the phenomenon is relatively rare. Regardless of the exact nature of pain indifference in schizophrenia, it can delay diagnosis and treatment of medical problems in these patients. Future studies in the field will need to pay attention to drug-induced extrapyramidal symptoms.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Singh, M K" uniqKey="Singh M">M. K. Singh</name></author><author><name sortKey="Giles, L L" uniqKey="Giles L">L. L. Giles</name></author><author><name sortKey="Nasrallah, H A" uniqKey="Nasrallah H">H. A. Nasrallah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murakami, H" uniqKey="Murakami H">H. Murakami</name></author><author><name sortKey="Tamasawa, N" uniqKey="Tamasawa N">N. Tamasawa</name></author><author><name sortKey="Yamashita, M" uniqKey="Yamashita M">M. Yamashita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Potvin, S" uniqKey="Potvin S">S. 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Mortensen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Potvin, Stephane" sort="Potvin, Stephane" uniqKey="Potvin S" first="Stéphane" last="Potvin">Stéphane Potvin</name></noRegion><name sortKey="Marchand, Serge" sort="Marchand, Serge" uniqKey="Marchand S" first="Serge" last="Marchand">Serge Marchand</name><name sortKey="Potvin, Stephane" sort="Potvin, Stephane" uniqKey="Potvin S" first="Stéphane" last="Potvin">Stéphane Potvin</name><name sortKey="Stip, Emmanuel" sort="Stip, Emmanuel" uniqKey="Stip E" first="Emmanuel" last="Stip">Emmanuel Stip</name><name sortKey="Stip, Emmanuel" sort="Stip, Emmanuel" uniqKey="Stip E" first="Emmanuel" last="Stip">Emmanuel Stip</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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